GIS-α in-vivo predictive dissolution tester

JMC (Japan Machinery Company)

Innovative Dissolution Tester widely experimented and evaluated at University of Michigan. Transfer model simulating stomach->duodenum->jejunum->ileum and also biphasic system.


GIS-α is a breakthrough dissolution tester for in-vivo prediction based on GIS (Gastro-Intestinal Simulator) widely experimented and evaluated at University of Michigan. You can set an appropriate transfer rate of dissolution buffer and rotational speed of paddles. In addition, various sizes of vessels are available to enable more precise in-vivo simulation compared to conditional dissolution testers. The buffer pH in each vessel is constantly monitored and recorded. The human GI condition is simulated by the buffer transfer in each compartment. This system can be used to predict an in vivo dissolution profile and give insightful information of in vivo dissolution of test oral compound. Transfer of each compartment and absorption of small intestine can be used as one experimental system.

Buffer transfer rate and rotational speed in each vessel can be individually programmed and pH in each vessel can be monitored and recorded. This system can adopt biphasic system in the vessel to assess the relationship between dissolution and absorption.


GIS-α is a very user-friendly system. For example, 12 peristaltic pumps in total can be calibrated easily via the touch screen.

Reproducibility of in vivo predictive dissolution profile is improved by enhancing peristaltic pump technology. Experimental conditions can be programmed and registered indefinitely in PC mode. Thus, it is easy to run one experiment to the next with different experimental condition. The cleaning of GIS-α system is similar to regular dissolution apparatus and is easy to set up to test many oral dosage forms.

Various studies have confirmed the effectiveness of GIS-α for in-vivo prediction especially for BCS class Ⅱ and Ⅳ drugs. Also, by full use of the functions of this system, you can try several ideas in research institute.

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